New drugs for prolonging longevity?
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In the realm of longevity, there are several drugs currently under investigation that are considered promising:
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Metformin: Initially used for diabetes management, metformin is being explored for its potential role in promoting longevity. While it is associated with some benefits, the decision to use metformin should be based on individual circumstances and medical advice 1.
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Rapamycin: Known for its effects on the mammalian target of rapamycin (mTOR) pathway, rapamycin is being studied for its potential to extend lifespan. However, Andrew Huberman and others caution about its side effects and emphasize the need for more conclusive data before considering it for longevity purposes 2.
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GLP-1 Agonists: These drugs, which influence the metabolism, are gaining attention not just for weight management but also for their potential in longevity. GLP-1 agonists are considered relatively safe compared to previous drugs like fenfen, though they also cause muscle loss, which can be a significant downside 3.
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Epitalon (Epithalamin): This peptide, secreted from the pineal gland, is associated with anti-inflammatory effects and the ability to adjust telomere length, which may contribute to cellular longevity. Epitalon is primarily researched for its impact on youth-related components and overall cell longevity 4.
It's essential to note that while these drugs show potential, other lifestyle factors such as quality sleep, nutrition, and exercise often have more substantial and proven benefits for longevity. Supplements and drugs should be considered secondary to these fundamental health practices, and always used under medical supervision.
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