How to measure biological age?

To measure biological age, several methods are discussed by Andrew Huberman and guest experts on the Huberman Lab. Two prominent methods include:

1. Epigenome Methylation: This involves measuring the methylation patterns on the DNA, particularly on certain parts of the epigenome. These patterns can indicate biological age, and lifestyle choices like smoking or lack of exercise can affect methylation in a way that might "age" the epigenome. Tests for this method might involve a simple mouth swab to assess these methylation patterns and determine biological age 1.

2. Ear Size Measurement: Another interesting, albeit less conventional method mentioned involves measuring ear size. The formula involves measuring the circumference of the ears in millimeters, making some calculations including average ear circumference and applying a specific formula (multiply the result by 1.96 after subtracting 88.1) to estimate biological age. This method is grounded in changes in collagen synthesis, which is part of the aging process 2.

These methods highlight the complex interplay of genetic and physical markers that can be used to assess one's biological age.