Which statins are preferred choices?

Preferred choices of statins, as discussed by experts on statins, include:

1. Atorvastatin (Lipitor) and Rosuvastatin (Crestor): These are high-intensity statins often prescribed due to their ability to significantly lower LDL cholesterol levels. They are recommended due to their effectiveness in reducing cardiovascular risks, especially in high-risk patients 1.

2. Pitavastatin (Livalo) and Pravastatin (Prevacol): Used less frequently but are considered when patients have issues with other statins, particularly due to fewer drug-drug interactions. Pravastatin, being a hydrophilic statin, is often preferred for its cleaner drug-drug interaction profile 2.

3. Simvastatin (Zocor): Mentioned as a moderate-intensity statin which, due to certain pharmacokinetic reasons involving numerous drug interactions, is less preferred unless other options are not suitable 1.

The choice of a specific statin can depend on various factors including a patient’s overall risk profile, potential for side effects, and other individual health conditions. For example, in patients with high-intensity cholesterol management needs, atorvastatin or rosuvastatin are often initiated at higher doses, while others like simvastatin might be prescribed cautiously due to interactions or in moderate doses 3 2.

Each patient's circumstances, including any chronic diseases they have, such as kidney disease that might require dosage adjustments, will influence the best statin choice for them 4.