Relationship between Creatine and Dht?

Creatine can influence the levels of dihydrotestosterone (DHT), a hormone derived from testosterone. This relationship between creatine and DHT has some implications, particularly regarding hair loss and other androgenic effects.

1. DHT Conversion: Creatine supplementation can slightly increase total testosterone and enhance the conversion of testosterone to DHT. This conversion is mediated by the enzyme 5-alpha reductase, which turns testosterone into DHT. Higher DHT levels are associated with several effects since DHT is a powerful androgen 1.

2. Hair Loss Myth: One common concern is that elevated DHT levels from creatine could lead to hair loss. DHT is known to bind to receptors on the scalp and promote male pattern baldness. However, Andrew Huberman and Dr. Kyle Gillett mention that while creatine might theoretically increase hair loss in individuals sensitive to DHT, it doesn't elevate androgen levels beyond normal physiological ranges. Therefore, the risk of accelerated hair loss from creatine is not substantial enough to warrant avoidance of the supplement for this reason 1 2.

3. Case-by-Case Basis: The effect of creatine on DHT and subsequent hair loss or other androgenic effects depends significantly on individual genetic predispositions. Some people might have more DHT receptors or heightened sensitivity to DHT, influencing their response to changes in its levels 2.

4. General Hormonal Impact: Creatine's ability to increase DHT might have some positive effects such as improved libido, strength, and cognitive benefits, aligning with DHT’s role in promoting those functions 1.

In summary, while creatine can increase DHT levels and potentially influence hair loss in sensitive individuals, its overall impact is generally within normal physiological ranges and varies widely based on individual genetics and hormone receptor distribution.