Toxicity of Fadogia Agrestis?

Fadogia agrestis, a supplement derived from a Nigerian shrub, has shown potential benefits such as an increase in luteinizing hormone and thereby testosterone. However, it also poses certain risks, particularly at high doses. Despite some evidence of testicular toxicity in animal studies, appropriate dosing for humans appears to mitigate these concerns.

Andrew Huberman highlights important considerations when using Fadogia agrestis:

• Stick to the recommended dosages and avoid exceeding them due to reported toxicity issues at high levels.
• Consider cycling the supplement (e.g., eight weeks on, two weeks off) to minimize potential negative effects.
• Use blood tests to monitor its impact on hormone levels and overall health.

Extended usage or large doses may pose risks; thus, users should exercise caution and regularly consult with healthcare providers (1).