What are safe MDMA dosages?

In discussing safe MDMA dosages, Andrew Huberman specifies that a typical dose explored in clinical studies is between 0.75 to 1.5 milligrams per kilogram of body weight. For instance, for a person weighing 100 kilograms, this range would translate to doses from 75 milligrams to 150 milligrams. He also mentions that in some clinical settings, an initial dose might be followed by a "booster" dose, approximately half the initial amount, given 90 minutes to two and a half hours into the session 1.

Moreover, the importance of dosage is linked to the drug's toxicity, which increases with higher dosages. The specific dosages used in research contexts or clinical interventions are crucial to evaluating MDMA's effects safely 1.