How do anti-histamines affect training?

Antihistamines can negatively impact some of the benefits of both cardiovascular exercise and resistance training. Andrew Huberman explains that these medications block mast cells, which are involved in the inflammatory process essential for muscle adaptation and repair. During and immediately after a workout, inflammation signals that the body needs to adapt and improve. Using antihistamines can disrupt this beneficial inflammatory process and, as a result, hinder gains in endurance, strength, and muscle size.

Additionally, non-steroidal anti-inflammatory drugs (NSAIDs) can have similar negative effects on training benefits. Be cautious with the use of these medications, especially within four hours before or after exercise, to maximize training benefits without interference 1 2.