How to lower SHBG

Lowering sex hormone-binding globulin (SHBG) can help increase free testosterone levels, which are critical for optimizing hormone profiles. Here are several strategies discussed by experts:

1. Aromatase Inhibitors: According to Peter Attia, using aromatase inhibitors can lower estradiol, which in turn may decrease SHBG levels. Additionally, monitoring thyroid function is important, as abnormal thyroid levels can affect SHBG production 1.

2. Supplements:

   • Boron: Dr. Kyle Gillette suggests that boron can acutely reduce SHBG levels, especially if someone's baseline boron intake is low. A dosage of 5 to 12 milligrams per day is recommended, although its effects might not be long-lasting 2.
   • Tongkat Ali: This supplement has been mentioned by Andrew Huberman as a potential agent to modulate SHBG and increase free testosterone, although the exact mechanisms remain unclear 1.

3. Dietary Adjustments: Increasing the intake of healthy carbohydrates can lower SHBG by stimulating insulin secretion, which suppresses SHBG production. This approach involves careful nutrient timing to leverage insulin's short half-life for SHBG reduction 3.

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     1

     Hormones and Health

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     2

     Hormone Optimization Insights

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     3

     Testosterone Therapy Insights

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     Hormones and Performance

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     5

     The Role of Genetics in SHBG Levels

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4. Medical Options: Anabolic agents like oxandrolone (Anavar) can strongly suppress SHBG and thereby liberate more free testosterone. However, caution is advised due to potential side effects and the need for concurrent testosterone therapy to maintain hormonal balance 4 5.

5. Factors Influencing SHBG: Genetics also play a role in determining baseline SHBG levels. Certain lifestyle factors, such as obesity and insulin resistance, can influence SHBG production. Addressing these through weight management and metabolic health improvements can be beneficial 5.

These insights show a range of strategies to consider, each with varying degrees of efficacy and safety profiles. It's essential to consult healthcare providers for personalized recommendations.