Nitric oxide precursors

Nitric oxide (NO) precursors have been a topic of discussion among experts, particularly regarding their effectiveness and proper application. Key insights from the retrieved information are:

• L-Arginine and L-Citrulline are common NO precursors. L-Arginine directly converts into nitric oxide via the enzyme nitric oxide synthase. However, according to Nathan Bryan, the body typically produces enough Arginine naturally and taking high doses might divert the metabolism away from NO production, leading to potential harm in individuals with endothelial dysfunction 1.

• L-Citrulline, though often marketed as a NO booster, is actually a byproduct of NO production and not an effective precursor. Bryan suggests there is no significant benefit to taking supplemental Citrulline for NO production 1.

• A more effective approach might be direct NO supplementation. Bryan's research includes developing a NO-lozenge that generates NO gas directly in the mouth, ensuring better absorption and immediate physiological effects 2.

• The oral microbiome plays a crucial role in converting dietary nitrates (from foods like arugula and beetroot) into NO. Regular use of mouthwash or fluoridated toothpaste can disrupt this process by eliminating necessary bacteria 3.

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    1

    Nitric Oxide Myths

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    2

    Nitric Oxide Insights

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    3

    Nitric Oxide and Oral Microbiome

    00:27:18
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    4

    Nitric Oxide Unveiled

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• Traditional NO supplements, such as those based on beetroot, are often found ineffective as many do not generate significant NO in the body despite claims and marketing 4.

In summary, while traditional NO precursors like L-Arginine and L-Citrulline have their roles, the body's ability to naturally produce sufficient amounts renders supplementation unnecessary and potentially harmful in some cases. Direct NO products and maintaining a healthy oral microbiome might offer more practical and effective benefits.