Andrew Huberman has discussed the benefits of garlic in relation to cardiovascular health and its ability to counteract specific negative effects associated with certain supplements. Here are the key points:

  1. Garlic and Allicin: Garlic contains a compound called allicin, noted for its impressive effects on the body, including reducing the levels of TMAO (Trimethylamine N-oxide) and potentially lowering LDL (low-density lipoprotein) cholesterol levels. Allicin is similar to the name Allison but spelled with two L's. Allicin and garlic, generally, may also have positive effects on cardiovascular tone and blood flow 1.

  2. Garlic Capsules: For practical benefits, 600 milligrams of garlic capsules can be taken daily. This is an efficient way to consume garlic, especially if one is taking supplements such as L-carnitine, which can increase the production of TMAO, a compound possibly linked to the stiffening of arteries. The garlic helps modulate this increase 2.

  3. Eating Garlic Versus Supplements: If consuming L-carnitine, especially in forms that are not very bioavailable, taking garlic (either as food or in capsules) helps mitigate potential rises in TMAO levels, benefiting cardiovascular health. Eating garlic directly or taking it in capsule form both provide benefits, depending on personal preference and practicality 1.

These discussions highlight garlic's role in supporting cardiovascular health particularly in conjunction with certain supplements, showcasing its protective properties against potential side effects such as increased TMAO levels.

Lcarnitine and Tmao

Kyle explains that Lcarnitine is a micropeptide that is not very bioavailable if taken orally and recommends 1 gram per day for fertility and androgen receptor upregulation. However, taking 10 grams of oral capsules is required to achieve this dose. Andrew and Kyle discuss the potential increase of Tmao with Lcarnitine intake and suggest taking 600 milligrams of garlic capsule for the allison to reduce Tmao.

Huberman Lab

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