What is Alpha-GPC?

Alpha-GPC, or alpha-glycerylphosphorylcholine, is a compound that can enhance both physical performance and cognitive function. It is taken in supplements form, typically in dosages of about 300 to 600 milligrams, to improve power output in activities like resistance training or sprinting, and for its cognitive effects, dosages can be as high as 1200 milligrams daily divided into three doses. Alpha-GPC has been shown to offset cognitive decline, particularly in older populations, and even improve cognition in people with Alzheimer's. It enhances power output, promotes fat oxidation, growth hormone release, and significantly supports skill learning by adjusting the foundation needed for executing tasks. Additionally, it increases acetylcholine transmission, which can directly improve cognitive function by increasing focus and concentration 1 2 3 4 5.

It's important to note that there have been some concerns regarding long-term use of Alpha-GPC, such as its potential link to an increased risk of stroke, which appears to be related to rises in a marker called TMAO associated with the cardiovascular system. However, it's suggested that taking garlic capsules might help offset increases in TMAO related to Alpha-GPC consumption 2.

Before starting any new supplement, it is always advisable to consult with a healthcare provider.