What is redox pairing?


Redox pairing involves the coupling of oxidation and reduction reactions, crucial for various biological processes. When one molecule loses electrons (oxidized), another gains them (reduced). An example highlighted by in a discussion with is the NAD/NADH pair. NAD (oxidized form) accepts electrons and converts to NADH (reduced form), playing a key role in cellular energy production through the electron transport chain within mitochondria 1.

The balance between NAD and NADH is critical. Too much NADH can disrupt cellular processes and produce harmful free radicals. Proper electron transfer and maintaining this balance are vital for efficient energy production and cell function 1.

Redox Pairing

Josh explains the difference between oxidation and reduction reactions and how they work together through electron transfer. He also discusses the importance of maintaining the right balance between NAD and NADH in the redox pairing process and how disruptions, such as cyanide poisoning, can quickly lead to mortality.

The Peter Attia Drive Podcast

216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.