What is the role of SHBG

Sex Hormone Binding Globulin (SHBG) plays a crucial role in binding and transporting androgens and estrogens in the body. It binds mostly to androgenic steroids like dihydrotestosterone (DHT), which is associated with prostate enlargement and male pattern baldness, as well as testosterone. It binds these hormones more strongly than it does estrogens (1). SHBG is vital for regulating the bioavailability of these hormones, deciding how much is free and available to tissues and how much remains bound and inactive. The level of SHBG can significantly influence physiological functions and conditions linked to androgen and estrogen levels.