What is PCSK Nine inhibitors?

PCSK9 inhibitors are a class of drugs used to lower cholesterol levels in the blood, particularly beneficial for individuals with familial hypercholesterolemia (FH), a condition characterized by extremely high cholesterol levels. These inhibitors work by targeting and blocking a protein called PCSK9, which normally degrades LDL receptors on liver cells. By inhibiting PCSK9, more LDL receptors are available to remove LDL cholesterol from the blood, thereby reducing overall cholesterol levels.

PCSK9 inhibitors are particularly effective for those who have genetic mutations leading to either hyperfunctioning or hypofunctioning PCSK9. The discovery of these drugs was inspired by the discovery of individuals with naturally low cholesterol who exhibited resistance to cardiovascular diseases due to their hypofunctioning PCSK9. These drugs are usually administered through injections and have been found to be very effective in managing cholesterol levels, significantly lowering the risk of heart disease 1 2.