• i need the circadian peaks in CT of AMPK, SIRT1, SIRT6, NrF2, PARP1, NAD and mTOR

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    There isn't specific information available from the retrieved data about the exact circadian peaks in CT (circadian time) for AMPK, SIRT1, SIRT6, NrF2, PARP1, NAD, and mTOR. However, I found some related insights into how these factors operate:

    1. AMPK, SIRT1, and mTOR: These are key pathways involved in metabolism and longevity, often interacting with each other. AMPK promotes mitochondrial activity and insulin sensitivity, while mTOR is involved in protein synthesis and cell growth. These pathways are influenced by activities like exercise and fasting, which tend to activate them in a coordinated manner, though the specific timing of these effects is complex and not definitively mapped out in circadian terms 1.

    2. NAD and Sirtuins: NAD levels are crucial for the activation of sirtuins, which play a role in regulating metabolism and aging. Increasing NAD can activate sirtuins, which then activate other genes involved in cellular health and longevity 2.

    To get precise timing for these biological factors, further detailed research papers or specific experimental data would be needed. These dynamics can depend on individual factors and specific environmental or physiological conditions.

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