Can ketone esters combat Alzheimer's?

Ketone esters show potential in combating Alzheimer's disease by providing the brain with an alternative energy source when glucose metabolism is impaired. Studies involving animal models of Alzheimer's disease have demonstrated beneficial effects of ketone esters, such as reduced amyloid accumulation and improved learning and memory functions 1.

Human studies, especially in individuals with mild cognitive impairment or early-stage Alzheimer's, indicate that despite issues with glucose utilization, brain cells can effectively use ketones 1. Moreover, ketone esters have shown promise not only in Alzheimer's but also in other neurodegenerative disorders such as Parkinson's disease 2.

Dr. Dominic D'Agostino mentions in another related episode that case reports and observational studies have noted improvements in cognitive function with ketone supplementation in Alzheimer's patients, particularly with the use of beta-hydroxybutyrate ester 3.

It's important to note, however, that more extensive clinical trials are needed to confirm these findings and to better understand the long-term effects and optimal usage of ketone esters in treating Alzheimer's disease.