What is the p53 pathway?


The p53 pathway is crucially involved in cellular functions related to the repair and regeneration of cells. Specifically, in the context of skin exposure to sunlight, ultraviolet B (UVB) light upregulates the activity of p53 in the skin's keratinocytes, which are a type of skin cell. This upregulation is necessary for downstream hormonal changes such as increases in ovarian and testicular size, testosterone, and estrogen levels. These data point to the importance of UVB light exposure for activating this pathway and influencing various physiological changes 1.

Sunlight and Hormones

Andrew discusses how sunlight exposure impacts hormones like testosterone and estrogen by activating the p53 pathway in keratinocytes. He recommends getting two to three exposures per week of at least 20 to 30 minutes of sunlight exposure onto as much of your body as possible, while also being mindful of cultural and safety constraints.

Huberman Lab

Using Light (Sunlight, Blue Light & Red Light) to Optimize Health | Huberman Lab Podcast #68