How effective are agmatine and Same?

Agmatine and SAMe (S-Adenosyl methionine) are noted for their effects on pain management. Andrew Huberman discusses their use in treating various forms of pain, including osteoarthritis and pain due to injuries. SAMe, in particular, has been shown to be as effective as over-the-counter drugs like naproxen in managing pain, although it may take longer (up to a month) to achieve pain-relief effects. The compounds act on dopamine and are seen as a non-prescription alternative to traditional pain medications 1.

For lumbar disc-associated pain, dietary agmatine sulfate has been reported to be safe and effective in alleviating pain and improving quality of life. Dosage regimens and duration of treatment are critical, and it's important to follow specific scientific recommendations 2.

Research and careful consideration of these supplements are advised, as their efficacy can vary depending on the exact conditions and individual responses.