How does kratom provide pain relief?
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Kratom provides pain relief primarily through its action on opioid receptors in the brain. Specifically, it activates the mu-opioid receptor system, which exists in parts of the brain including the brainstem. This activation leads to analgesia (pain relief) as well as mild sedation and euphoria 1.
Kratom binds to mu-opioid receptors similarly to opioids like morphine and hydrocodone, although it is generally less potent. This binding results in effects comparable to other opioids, including the ability to provide significant pain relief and mild euphoria 2. If the mu-opioid receptors are blocked before taking kratom, the typical effects of kratom, such as pain relief and euphoria, do not occur, underscoring its opioid-like function 1.
It's crucial to note that variations in kratom products can lead to different effects, as different brands may contain varying levels of active alkaloids, which impact how much they affect the opioid system. Therefore, kratom's effectiveness and safety profile can vary significantly 3.
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