Benefits of metformin and resveratrol?

Andrew Huberman discussed the benefits of metformin and resveratrol with David Sinclair in an episode of the Huberman Lab.

Resveratrol, taken in the morning, helps align with the body's natural circadian rhythms, potentially boosting NAD (nicotinamide adenine dinucleotide) levels. Increased NAD can improve insulin sensitivity, energy levels, and overall vitality. Anecdotal evidence from athletes suggests improvements in performance and endurance when following a protocol that includes resveratrol 1.

For metformin, David Sinclair mentioned its role in managing blood glucose levels and improving metabolic health. Both resveratrol and metformin, when taken together, might have synergistic effects on longevity and anti-aging processes.

Overall, these substances show promise in enhancing metabolic function, energy, and potentially lifespan, but clinical evidence is still emerging 1.