What are alternatives to SAMe?

Andrew Huberman mentions that some people are opting for alternatives to SAMe (S-Adenosyl methionine) by focusing on precursor molecules like 5-MTHF (5-methyl tetrahydrofolate). The idea is to increase SAMe levels naturally by enhancing the body's own production of it. This method involves supplementing with 5-MTHF, which is upstream in the metabolic pathway that produces SAMe 1.

Another option discussed by Dr. Huberman is agmatine sulfate, which may offer benefits for pain management similar to SAMe. Agmatine has been studied for its efficacy in alleviating pain associated with lumbar disc issues and has shown limited side effects when used under specific dosage regimens 1.

Both 5-MTHF and agmatine are explored as alternatives to SAMe by focusing on enhancing the body's natural chemical pathways or targeting pain management through different mechanisms 2 1.