What is mitophagy?

Mitophagy is a specialized form of autophagy specifically targeting mitochondria. It plays a crucial role in cellular health by identifying and recycling old or defective mitochondria, thus ensuring the replacement with new, functional ones. This process can be significantly stimulated by fasting or calorie restriction, which is why such dietary practices are often associated with promoting longevity and improving overall health. Mitophagy helps prevent mitochondrial dysfunction, which is linked to numerous chronic diseases and age-related conditions 1.