What is Chaperone mediated autophagy?

Chaperone-mediated autophagy (CMA) is a specific type of autophagy process identified within the broader realm of cellular autophagy mechanisms. It is primarily engaged during prolonged fasting periods, typically around the second or third day without food. This process is distinctly involved in the deep cleansing of proteins that are old or misfolded within the body.

David Sinclair, a biologist interviewed on the Huberman Lab, describes it as a "deep cleanse" that starts to occur after a couple of days of fasting. CMA helps to purge the cells of these damaged proteins, contributing to cellular maintenance and potentially increasing longevity. Sinclair cites research suggesting significant benefits in longevity from this process, noting experiments where triggering CMA in older mice extended their lifespan by 35% 1.