Can HRT reduce Alzheimer's risk?
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Yes, hormone replacement therapy (HRT) may have potential benefits in reducing the risk of Alzheimer's disease, but the timing of initiation is critical.
According to a discussion between and , early initiation of HRT, around the time of menopause, appears to be beneficial, particularly for women carrying the ApoE4 gene. Conversely, late initiation of HRT might increase Alzheimer's risk. Therefore, starting HRT early, closer to menopause, could be advantageous for reducing the risk of Alzheimer's and other conditions like cardiovascular disease and bone density loss 1.
However, there is still some uncertainty, and more research is needed to fully understand the long-term effects and optimal timing of HRT. Peter Attia mentioned that once estrogen therapy is stopped, there might be some risks associated with conditions such as bone density loss, but the exact implications for Alzheimer's and other diseases are not entirely clear yet 2.
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