Dutasteride vs. Finasteride?

Dutasteride and Finasteride are both used to promote hair growth by inhibiting the 5-alpha reductase enzyme, which decreases dihydrotestosterone (DHT) levels, a key factor in hair loss. Here's a comparison of the two based on information provided by Andrew Huberman:

Dutasteride

• Potency: More potent than Finasteride, inhibiting all three isoforms of 5-alpha reductase. It can reduce DHT by up to 95% even at lower doses (0.5 to 2.5 milligrams orally).
• Speed: Works two to five times faster than Finasteride in inducing hair regrowth.
• Side Effects: Associated with significant side effects related to DHT suppression, such as decreased sex drive, increased estrogen and prolactin levels, and possibly gynecomastia (male breast tissue growth) due to its strong inhibition of DHT 1.

Finasteride

• Potency: Less potent, primarily inhibits one type of 5-alpha reductase isoform.
• Effectiveness: Can increase hair count by approximately 20% and reduces hair loss in about 90% of users.
• Side Effects: Known for significant side effects if not dosed properly; side effects vary among individuals based on the amount of the different 5-alpha reductase isoforms they produce. Finasteride is typically associated with fewer side effects compared to Dutasteride 2.

In summary, while Dutasteride acts faster and more potently, it comes with a higher risk of severe side effects. Finasteride, while slower and slightly less effective in rapid regrowth, tends to have fewer side effects, making it a safer option for long-term use. Both drugs require careful consideration due to their impact on hormone levels and potential side effects. Always consult healthcare professionals before starting treatment with these medications.