Importance of pH levels in metabolism?

The pH levels within the human body are crucial for numerous metabolic functions and are tightly regulated by numerous biological mechanisms. Andrew Huberman explains that while different cells and tissues across the body may exhibit varying pH values, these levels are generally maintained within a very narrow range to ensure the proper functioning of cellular processes.

He notes that the body's pH is strongly homeostatically regulated, meaning that it doesn't change much under normal conditions. The pH in certain parts of the gut, for example, can be more acidic, which is essential for the flourishing of gut microbiota. These microbiota play a critical role in regulating everything from neurotransmitter production to hormone production. However, the overall cellular pH, except in conditions like severe blood loss, remains relatively stable 1.

Furthermore, breathing and the associated levels of carbon dioxide in the blood also influence body pH. Higher carbon dioxide levels can decrease blood pH (making it more acidic), whereas lower carbon dioxide levels increase pH (making it more alkaline). The body generally aims to maintain a pH of around 7.4, although specific requirements can vary, such as in the gut where a slightly more acidic environment is beneficial for microbial health 2.