Can lifespan be extended in mice?

Yes, lifespan can be extended in mice. Dr. Matt Kaeberlein discussed various interventions tested under the National Institute on Aging's program, which showed some small molecules can extend lifespan in mice. Notably, the program, conducted across multiple sites for replication, found molecules like rapamycin and acarbose effective in extending mouse lifespan, although the effect is sometimes sex-specific, often favoring males 1.