Can lifespan be extended in mice?


Yes, lifespan can be extended in mice. Dr. Matt Kaeberlein discussed various interventions tested under the National Institute on Aging's program, which showed some small molecules can extend lifespan in mice. Notably, the program, conducted across multiple sites for replication, found molecules like rapamycin and acarbose effective in extending mouse lifespan, although the effect is sometimes sex-specific, often favoring males 1.

Extending Lifespan

Dr. Matt Kaeberlein discusses the National Institute on Aging's program to test interventions in mice for extending lifespan. He explains that certain small molecules have shown promising results in extending lifespan in mice, with some favoring males over females. The conversation also touches upon potential drugs like metformin and NAD precursors that could extend health span.

Tim Ferriss Show

The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show