What is Berberine?

Berberine is a compound derived from various plants and tree bark. It is known for its potent ability to reduce blood glucose levels, similar to prescription drugs like Metformin and Glibenclamide. Berberine activates the AMPK pathway, which is associated with fasting and low blood glucose states, making it effective in managing blood sugar levels 1.

However, Berberine should be used cautiously. It can cause significant drops in blood glucose, particularly when taken on an empty stomach or without adequate dietary carbohydrates, leading to symptoms like hypoglycemia, headaches, and dizziness 2. Despite these risks, Berberine is also noted for its potential to lower total cholesterol and reduce insulin levels marginally 3.

Andrew Huberman emphasizes the importance of consulting a healthcare provider before using Berberine, especially due to its strong effects and potential side effects 2.