Why are glycine and proline important?

Glycine and proline are pivotal for several reasons, primarily concerning collagen and metabolic processes.

1. Collagen Production: About 33-35% of collagen is made up of glycine, and around 25% includes proline along with hydroxyproline 1 2. Collagen is critical for the structural integrity of tendons, ligaments, cartilage, skin, gums, muscle, and the gut.

2. Wound Healing: Proline plays an essential role in wound healing. After a wound occurs, proline levels at the site become significantly higher than in plasma, which suggests its active transport and necessity in the healing process 1 2.

3. Energy Production: Proline can be converted into glutamate and alpha-ketoglutarate to be used by mitochondria to produce energy. This conversion is particularly useful during catabolic states when glucose levels drop, as proline is released from connective tissues 1 2.

4. Anti-Inflammatory: Glycine functions as an anti-inflammatory signaling molecule and acts as an inhibitory neurotransmitter in the brain. This could contribute to its wider role in health beyond collagen synthesis 2.

Citation

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    1

    The Power of Collagen

    01:25:29
    
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    2

    Benefits of Hydrolyzed Collagen

    00:12:36