Can training delay brain deterioration?

Yes, training can indeed delay brain deterioration. Dr. Matt Kaeberlein discussed on the Tim Ferriss Show that interventions like rapamycin have been shown to delay age-related declines in various tissues, including the brain. This has been substantiated in normal aging contexts and in mouse models of Alzheimer's and other neurodegenerative diseases, where improvements in function and behavioral tests have been noted 1.

Furthermore, Tim Ferriss, during his discussion with Dr. Peter Attia, highlighted the importance of strength training in maintaining brain function. He theorized that the deterioration of brain function over time might be delayed by specific kinds of training that replicate critical movements, suggesting that changes due to aging could be counteracted by maintaining an active training regimen 2.