Is the widely used drug truly safe?

The safety of widely used drugs can vary greatly depending on the specific medication in question. Here are insights from experts on two commonly discussed drugs:

1. Acetaminophen (Paracetamol): This over-the-counter pain reliever is generally considered safe when used as directed. However, it can be extremely toxic to the liver in cases of overdose. The liver metabolizes acetaminophen, but a small portion of it is converted into a toxic metabolite called NAPQI, which can damage liver cells if not neutralized by glutathione. Excessive intake of acetaminophen can deplete glutathione levels, leading to liver necrosis and potentially severe liver damage. Additionally, chronic alcohol consumption or use of certain other drugs can exacerbate this risk by interacting with the liver’s metabolism pathways 1.

2. GLP-1 Receptor Agonists (e.g., Ozempic): Often used for managing diabetes and obesity, these drugs have been scrutinized for long-term safety. Research, such as that by Professor Jean Luc Faille in France, has indicated a potential increase in thyroid cancer risk among users. His study found that diabetics who took these drugs for at least three years exhibited a 50% to 75% higher risk of developing thyroid cancer compared to those who did not. This finding has sparked further investigation, although regulatory agencies like the European Medicines Agency have not yet been convinced by the evidence 2.

These examples underscore the importance of adhering to dosage recommendations and being aware of potential interactions and long-term risks associated with any medication. Always consult with healthcare providers for personalized advice and before making any changes to medication routines.