Can glutamine offset sugar cravings?

Yes, glutamine can help offset sugar cravings. According to Andrew Huberman, supplementing with the amino acid glutamine has been reported to reduce sugar cravings. This effect is likely because glutamine can activate certain neurons in the gut that are also responsive to sugar, thereby providing an alternative stimulus to those neurons that normally crave sugar. This hypothesis is based on the biological function of these neurons and the pathways they engage in the brain. It's important to start with modest amounts of glutamine to avoid gastric distress, and you should consult with a healthcare provider before starting supplementation, especially if you have a pre-existing condition like cancer 1 2.