Effectiveness of resveratrol and nad?

Resveratrol and NAD (specifically its precursors NR and NMN) have been discussed in terms of their roles and effectiveness in several aspects of health and longevity.

Resveratrol

• Absorption and Dosage: Resveratrol, when supplemented, requires a sizable dose to be effective, far more than one could consume through diet alone (such as drinking red wine). Dr. David Sinclair, a guest on the Huberman Lab, recommends a dosage of 1000 milligrams per day, ideally taken with a fatty substance like olive oil to enhance absorption. He emphasizes the importance of using pure resveratrol supplements, as contaminated or degraded resveratrol can cause adverse effects like diarrhea 1.
• Mechanism: Resveratrol acts as an activator of the sirtuin pathways, which are involved in the body's defenses against aging. Dr. Sinclair notes that resveratrol was the most effective among the tens of thousands of molecules tested in activating sirtuin-related enzymes 2.

NAD and its Precursors (NR and NMN)

• Effectiveness of NAD Infusions: NAD infusions are assumed to be more effective at increasing cellular levels of NAD compared to oral supplements like NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide). However, the direct comparisons and impacts of these interventions on lifespan are still subjects of ongoing debate and research. Dr. Huberman himself uses NAD infusions for their vitality and energy-boosting effects, despite admitting they are expensive and uncomfortable 3.
  • 

    1

    Resveratrol Protocols

    00:50:29
    
  • 

    2

    Sirtuins and Aging

    00:56:47
    
  • 

    3

    NAD and Longevity

    00:15:49
    
  • 

    4

    NAD and Aging

    00:59:23
    
  • 

    5

    Energy and NAD Boost

    00:09:39
    
• Comparison of NR and NMN: Dr. Sinclair on the Huberman Lab points out that NMN can directly increase NAD levels significantly if taken over a period, based on clinical trials (still unpublished) he has conducted. According to him, NMN contains all the necessary components for the body to efficiently produce NAD, unlike NR, which lacks phosphate and does not increase energy levels or improve physical capabilities in the same way as NMN in animal studies 4.

General Consideration

• Supplements vs. Lifestyle: Both Dr. Huberman and Dr. Sinclair emphasize that while supplements like resveratrol and NAD can be beneficial, they should be considered as supplements to, not replacements for, a healthy lifestyle that includes proper diet, exercise, and stress management 3 5.

These discussions suggest specific protocols for using these substances effectively and raise important considerations for their role in health and aging, pointing to the importance of ongoing research and individual consultation with health professionals.