"Dosage nad+ subcutaneously

When discussing the subcutaneous administration of NAD+ (nicotinamide adenine dinucleotide), several insights emerge from recent expert discussions.

1. Bioavailability: Subcutaneous administration provides about 80% bioavailability for NAD+, compared to around 100% with intravenous methods. This makes it a viable yet less effective alternative:

   • Dr. Craig Koniver stated that while intravenous (IV) methods yield the best absorption, subcutaneous injections are worthwhile for those unable to access IV therapy. He referred to administering approximately 100 mg subcutaneously to achieve benefits, adding that this may cause slight stomach cramping for some individuals 1.

2. Dosing: Experts recommend different dosages depending on individual needs:

   • Dr. Koniver mentioned that a typical loading dose for NAD+ is around 750 mg intravenously, followed by monthly maintenance doses. For those using subcutaneous methods, he noted starting with around 100 mg for five consecutive days 1.
   • Sandra Kaufmann emphasized the importance of individualized dosing, avoiding specific figures, but hinted that a common practice is taking only a third of the recommended dosage stated on product labels, adapting to individual body weight and health conditions 2.

3. Advantages of Subcutaneous Administration: This method offers convenience and can be easier for self-administration compared to IV infusions. It is particularly beneficial for individuals who may not have easy access to clinical settings for intravenous therapies 1.

These insights highlight the potential practicality of subcutaneous NAD+ use while also underscoring the need for caution and personalized approaches in dosing.