What is cissus quadrangularis?

Cissus quadrangularis is a supplement that has been found to significantly increase serotonin levels when taken in dosages of about 300 to 600 milligrams. Studies have shown that it can increase serotonin by 30% to 39%, which can lead to decreased appetite, potentially aiding in weight loss. However, it is important to note that cissus quadrangularis may need to be cycled to avoid potential side effects, though specific cycling recommendations (like two weeks on, two weeks off or more frequent cycling) are still a matter of debate due to limited data. Thus, while it may be beneficial for appetite and weight control through serotonin regulation, users should approach its usage with caution 1.