Uric acid

Uric acid has been discussed by Andrew Huberman in relation to several health aspects:

1. Relation to Mania: Uric acid was investigated by researcher Cade, who hypothesized its connection with mania. Cade found that injecting uric acid into guinea pigs induced mania-like symptoms, which led to the use of lithium to dilute uric acid, resulting in the discovery of lithium urate—a compound used in psychiatric treatments 1.

2. Metabolic Effects: Uric acid is a byproduct of glucose metabolism. It's formed during the conversion processes in the body and can affect health by inhibiting mitochondrial function and reducing the activity of endothelial nitric oxide synthase—a key enzyme for managing blood pressure. High levels of uric acid can lead to increased blood pressure and could potentially impair vascular and mitochondrial function 2.

These insights highlight the significance of uric acid in both neurological and metabolic health contexts.