SARMs

Tim Ferriss has discussed SARMs (Selective Androgen Receptor Modulators) on his podcast with experts like Dom D'Agostino and Patrick Arnold. Here are a few key points from those discussions:

1. Intended Design and Use:

   • SARMs are designed to minimize androgenic effects (such as those leading to secondary sexual characteristics) while still offering anabolic (muscle building) benefits. This could make them safer alternatives to traditional anabolic steroids, particularly for individuals with conditions like muscle wasting diseases or cancer cachexia 1.

2. Current Limitations:

   • While SARMs have shown promise, they currently have limitations. For instance, achieving a complete separation of anabolic and androgenic effects is challenging. Higher dosages of SARMs still bring about unwanted androgenic effects and problems like the suppression of natural testosterone production (HPTA shutdown) 2.
   • SARMs also haven't fully solved issues like hepatotoxicity (liver damage) associated with many anabolic agents 2.

3. Potential in Medical Treatments:

   • Dom D'Agostino highlights that some SARMs have been developed with the aim of treating cancer cachexia and similar conditions. Studies suggest that within certain dosages, anabolic agents do not necessarily promote cancer growth and could be beneficial for preserving muscle mass in patients undergoing treatments like chemotherapy 3.
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       1

       SARMs vs. Steroids

       00:38:53
       
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       2

       Understanding SARMs

       02:19:18
       
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       3

       Anabolic Agents in Cancer

       00:34:50
       

4. Research and Development:

   • There is ongoing research by several pharmaceutical companies to develop more effective and safer SARMs. However, these compounds have yet to fully reach their potential as replacements for traditional anabolic steroids 1.

These insights can be found in episodes of the Tim Ferriss Show with Dom D'Agostino and Patrick Arnold.