• is methylene blue safe

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    The safety of methylene blue largely depends on its use, dosage, and individual health conditions.

    Methylene blue, commonly used to treat methemoglobinemia, has benefits such as cognitive enhancement, mitochondrial health improvement, and potential anti-aging effects. However, it is not without risks. Key safety considerations include:

    1. Dosage and Quality: Recommended doses generally range from 1 to 4 mg per kg of body weight. It is crucial to use pharmaceutical-grade methylene blue to avoid impurities 1 2.
    2. Interactions with Medications: Methylene blue can interact with serotonin-affecting medications like SSRIs, posing the risk of serotonin syndrome. It is also contraindicated for individuals with conditions like G6PD deficiency, kidney or liver issues, and for those on MAOIs 2 1.
    3. Side Effects and Caution: Potential side effects include blue urine and stool, gastrointestinal disturbances, and allergic reactions. Overuse can cause fatigue and dependence issues, emphasizing the need for cycling its use (e.g., ten days on, three days off) 3 4.
    4. Medical Supervision: Due to its potent effects and risks, it is recommended to consult healthcare providers, especially when using it alongside other treatments 1 5.

    Use methylene blue carefully and under medical supervision to maximize benefits and minimize risks.

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