Does kratom suppress respiration?

Andrew Huberman explains that kratom does not typically suppress respiration at low to moderate dosages. However, when combined with other opioids or substances like alcohol, kratom can suppress respiration. There is evidence that kratom-induced deaths may be due to respiratory suppression, particularly at higher dosages, indicating a real risk when escalating usage levels. Therefore, while kratom on its own at recommended dosages rarely causes fatal respiratory suppression, its potential dangers, especially in combination with other substances or at high doses, should not be underestimated 1.