When are aromatase inhibitors necessary?

Aromatase inhibitors are generally not necessary for most people according to Andrew Huberman and Dr. Kyle Gillett. They suggest that inhibiting estrogen through aromatase inhibitors can disrupt brain function, cause connective tissue issues, and reduce libido. Instead, it is often more effective to use lifestyle interventions and supplements like calcium D-glucarate to manage estrogen levels 1.

Dr. Kyle Gillett mentions that only in very rare cases, where individuals have an extremely active aromatase gene, might aromatase inhibitors be necessary. Such cases could involve conditions like puberty gynecomastia (breast tissue growth in males), especially when it occurs despite the absence of other risk factors and can even affect lean individuals 1.