How do statins and bempidoic acid work?

Statins and bempidoic acid are two medications used to lower cholesterol, but they work through different mechanisms.

1. Statins: These drugs inhibit cholesterol synthesis globally in the body. They do this by blocking the enzyme HMG-CoA reductase, which is crucial for the production of cholesterol in the liver. Statins are known for their potency in reducing cholesterol levels but may have side effects, which can include muscle pain and, in rare cases, cognitive issues, although clinical trials have not conclusively shown these effects 1.

2. Bempidoic Acid: This medication also blocks cholesterol synthesis but only in the liver. It targets a different enzyme than that affected by statins. As a result, bempidoic acid has a similar cholesterol-lowering effect but with fewer side effects compared to statins. This makes it a useful alternative for patients who experience adverse effects from statins 1.

Both drugs are part of efforts to manage cholesterol levels and reduce the risk of cardiovascular diseases, but their differing mechanisms and side effect profiles offer options for individualized patient care.