Niacin as a supplement

Niacin, also known as vitamin B3, plays a crucial role in numerous biological processes including energy metabolism, DNA repair, and anti-aging mechanisms. Dr. Andrew Huberman and Dr. David Sinclair discussed niacin's potential impact on aging through its effect on sirtuins—proteins that regulate cellular health and longevity. These sirtuins require NAD, a molecule for which niacin serves as a precursor. Niacin can thus play a role in supporting cellular functions that are crucial for aging and disease prevention 1.

Additionally, it's important to consider niacin within the broader context of a supplementation regimen. Dr. Huberman emphasizes the importance of consulting with a healthcare provider before starting any new supplement, especially if it involves complex processes like those related to cellular repair and aging. The dialogue on niacin and similar compounds underscores a multidimensional approach to supplementation, where the focus is on biological effectiveness and safety 1.