Omega-3 to omega-6 ratio?

The omega-3 to omega-6 ratio has profound effects on depression and mood. Increasing this ratio by having higher omega-3 levels can lead to less learned helplessness, as shown in both animal studies and human clinical trials. In human studies focusing on major depression, a comparison was made between 1000 milligrams per day of EPA (a component with a high level of omega-3) and 20 milligrams of fluoxetine (Prozac). EPA proved to be equally effective in reducing depressive symptoms over the course of eight weeks and even had a synergistic effect when combined with fluoxetine 1.

Adjusting this ratio can also significantly lower inflammation markers and improve the effectiveness of antidepressants at lower doses by increasing heart rate variability. Also, omega-3 has been associated with positive effects on heart conditions like heart rate variability 2.