Does psilocybin increase neuroplasticity
Does psilocybin increase neuroplasticity
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Psilocybin indeed increases neuroplasticity. According to Andrew Huberman, both structural and functional plasticity are observed in the human and animal brain following psilocybin administration. This involves the growth of new dendritic spines and the addition or strengthening of new neural connections, predominantly in the frontal cortex, but also potentially in other brain areas like the visual cortex and subcortical regions 1 2 3.
Neurogenesis and Neuroplasticity
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Huberman Lab
He notes that the effects are often seen after therapeutic doses, ranging from 10 to 30 milligrams per session. These structural changes can persist beyond the active presence of psilocybin in the brain, potentially explaining the prolonged therapeutic benefits observed in some individuals 4.
Psilocybin achieves these neuroplastic effects primarily by activating the serotonin 2A receptors, leading to increased serotonin levels, which in turn facilitate broader brain connectivity and plasticity 5 6. The therapeutic window for these effects can be influenced by various factors, including the dosage and the specific conditions under which the psilocybin is consumed 7 8.
Overall, Dr. Huberman emphasizes that while psilocybin stimulates neuroplasticity, it is crucial for this plasticity to be adaptive to ensure it provides therapeutic benefits 3.