What is Bdnf and how is it stimulated?

BDNF, or Brain-Derived Neurotrophic Factor, is a crucial molecule in the brain that plays a significant role in neuroplasticity. It promotes the survival and growth of neurons, influences their shape, and enhances the sensitivity of neurons to input by facilitating the insertion of new glutamate receptors. BDNF binds to TrkB receptors on neurons, initiating a cascade of biological processes that contribute to neural plasticity and overall brain health. It is often described as acting somewhat like a fertilizer for neurons, although this simplification underrepresents the extensive scope of its functions 1.

Stimulation of BDNF can occur through several pathways, prominently during physical exercise. Exercise induces the release of proteins like myokines from muscles and ketones like beta-hydroxybutyrate from the liver, both of which can cross the blood-brain barrier and stimulate the production of BDNF in the brain. This process significantly contributes to the growth of new brain cells, particularly in the hippocampus, enhancing cognitive functions and emotional health 2.