Does nicotine suppress appetite?

Yes, nicotine does suppress appetite. According to Andrew Huberman, nicotine achieves this by binding to specific nicotinic receptors in the brain, particularly the alpha-4-beta-2 receptors. This interaction activates POMC neurons in the hypothalamus, which play a significant role in reducing hunger and the desire to chew food 1 2.

Additionally, nicotine's effects on metabolism can also contribute to its appetite-suppressing properties. While the increases in metabolism are relatively small (about 2-5%), they are sufficient to influence appetite and energy expenditure 2. This dual action of both appetite suppression and metabolism enhancement makes nicotine a potent agent in reducing food intake 3.