Ketone Salts

Tim Ferriss has not personally spoken about ketone salts on his podcast, "The Tim Ferriss Show." However, there are discussions featuring guest Dom D'Agostino, who is an expert on the topic of ketones. Here's a summary of insights based on what Dom D'Agostino has shared:

1. Efficacy of Ketone Salts: Dom D'Agostino has discussed ketone salts, specifically racemic beta hydroxybutyrate salts, as potentially effective in treating fatty acid oxidation disorders like multiple acyl COA dehydrogenase deficiency. He mentions studies that demonstrate positive outcomes from using these exogenous ketones and emphasizes the need for more research into their medical and performance applications 1.

2. Safety and Side Effects: Regarding safety, D'Agostino has noted that no significant adverse medical side effects have been reported with the use of ketone salts except for possible digestive discomfort at high doses. He believes that proper balancing of minerals in ketone salt compositions is crucial 2. Additionally, D'Agostino has countered some concerns about the safety of DL beta hydroxybutyrate salts, explaining their widespread usage and highlighting their benefits from the large number of doses already consumed 3.

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     1

     Ketone Salts Explained

     01:24:38
     
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     2

     Ketone Salts Insights

     01:16:00
     
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     3

     Ketone Salt Safety

     01:12:27
     
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     4

     Ketones and Cancer

     01:49:29
     
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     5

     Exogenous Ketones Explained

     01:15:29
     
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     6

     Exogenous Ketones Explained

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     7

     Ketogenic Diet Insights

     01:21:38
     

3. Use of Exogenous Ketones: In terms of personal use for health optimization, D'Agostino has shared that he would take exogenous ketones to increase his ketone levels by one to two millimolars, particularly if he had a condition like glioblastoma. He suggests that medium-chain triglycerides (MCT) powder and certain ketone salt products can be used to achieve this 4.

4. Controversy and Advancements: D'Agostino has weighed in on the debate over the use of exogenous ketone salts and differentiates between scientific facts and opinions regarding their usage. While some experts have expressed concerns, D'Agostino has defended the use of these supplements, backed by his research and experience 5 6.

5. Relationship with the Ketogenic Diet: Contextualizing within the ketogenic diet, he underlines the importance of understanding the variations of the diet and determining the optimal fatty acid profile for health benefits. He discusses ketone esters' remarkable neuroprotection against central nervous system (CNS) oxygen toxicity and challenges the notion that high dietary fat intake is inherently dangerous 7.

These insights demonstrate Dom D'Agostino's knowledge and perspective on ketone salts, which may align with interests related to Tim Ferriss's discussions on health and performance optimization.