What is the mechanism of SSRIs?

SSRIs, or Selective Serotonin Reuptake Inhibitors, work by preventing the reuptake of serotonin in the synapse, the gap between neurons where neurotransmission occurs. This inhibition allows more serotonin to remain available in the synapse, thereby enhancing its functional impact on the receiving neuron. Essentially, SSRIs don't increase the overall amount of serotonin in the brain; instead, they improve the efficacy of the serotonin that is already present, making it more effective at modulating neuronal activity 1.

Examples of SSRIs include medications like Prozac (fluoxetine) and Zoloft (sertraline). These drugs are commonly prescribed for depression and various anxiety disorders due to their ability to enhance serotonin signaling 1.