b6

Vitamin B6, or pyridoxine, is an important nutrient that plays a vital role in the body. It is involved in the metabolism of amino acids, the production of neurotransmitters, and various other biochemical processes. However, there has been some discussion about the safety and proper forms of B6 supplementation.

• Dave Asprey and Izabella Wentz highlighted concerns with synthetic B6 (pyridoxine hydrochloride). They noted that it could lead to accumulations of an intermediate metabolite in the body with a long half-life, which may result in neuropathy. They recommend using P5P (pyridoxal 5'-phosphate), the active form of B6, in smaller doses, as it doesn't convert to the problematic intermediary metabolite 1.

• Teri Cochrane agrees about the importance of using the right form of B6, mentioning that non-chelated versions can cause issues like high blood B6 levels, which mean you are not assimilating it properly. High blood B6 levels often indicate that the wrong form of the vitamin is being taken 2.

• Dan Freed and Dave Asprey talked about the need for using the proper form of B6, P5P, and the problems with the synthetic form, pyridoxine HCl, which can clog receptors and is not properly converted to the active form. The congested receptors can remain so for upwards of 1000 days 3.

  • 

    1

    The B6 Controversy

    00:24:42
    
  • 

    2

    B6 Deficiency Insights

    00:58:26
    
  • 

    3

    Unlocking the Power of Vitamin B6

    00:45:53
    
  • 

    4

    Methylation and Choline Requirements

    02:00:44
    
  • 

    5

    Prolactin and Motivation

    00:42:21
    
  • 

    6

    Genetic Strategies

    00:45:35
    

• Chris Masterjohn noted that for patients with high homocysteine levels, supplementing with methylated forms of B vitamins, such as methyl folate and methyl B12, can be important. If homocysteine levels do not decrease, it might indicate that these vitamins are not addressing the deficit and other nutrients, such as B6 or trimethylglycine (TMG), should be considered 4.

• Andrew Huberman mentioned that B6 and zinc together can act as prolactin inhibitors. By suppressing prolactin, they increase dopamine, which has a functional effect that can aid in motivation and potentially boost testosterone levels indirectly 5.

• Dr. Ben Lynch highlighted the crucial role of B6 in converting 5-hydroxytryptophan (5-HTP) to serotonin. He pointed out that if individuals are taking 5-HTP and not seeing results, it might be due to a lack of B6 6.

If you are considering B6 supplementation, it is recommended to consult with a healthcare provider to ensure the proper form and dosage.