Is nasal testosterone effective?

Nasal testosterone, such as Natesto, can be effective but comes with unique considerations. Peter Attia and Derek discuss that Natesto, a nasal formulation, has a very short half-life, requiring administration three times a day. This frequent dosage mimics the natural diurnal rhythm of testosterone levels, potentially leading to fewer side effects compared to less frequent, higher-dose injections.

Benefits of Natesto include reduced risk of overproducing red blood cells, which is a concern with other testosterone replacement therapies. Additionally, it is an FDA-approved formulation, making it safer and more reliable for both men and women. For women, it can be used as an on-demand libido enhancer, and there are ongoing studies exploring its use for improving orgasmic function 1.

However, its practicality might be a challenge due to the need for frequent daily applications, which may not be convenient for long-term use 1.